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Catalytic synthesis of dihydropyridines by domino reaction of terminal alkynes, carbodiimides, and acetylenic esters

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Abstract

A novel additive-assisted reaction for the synthesis of dihydropyridines using copper salts as catalyst has been described. The (imino)pyridine skeletons were obtained in acceptable yields through a domino reaction involving terminal alkynes, carbodiimides, and acetylenic esters. Control experiments were conducted to explore the reaction path and to prove the mechanism proposed for the reaction.

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Acknowledgements

We wish to thank for a grant from the Islamic Azad University, South Tehran Branch.

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Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Science, South Tehran Branch, Islamic Azad University, Tehran, Iran

    Mozhgan Sadat Jalali, Mohammadreza Manafi, Seyed Saied Homami & Banafsheh Gorji

  2. Department of Polymer and Textile Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran

    Amirhossein Monzavi

Authors
  1. Mozhgan Sadat Jalali
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  2. Mohammadreza Manafi
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  3. Seyed Saied Homami
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  4. Banafsheh Gorji
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  5. Amirhossein Monzavi
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Correspondence to Mohammadreza Manafi.

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Jalali, M.S., Manafi, M., Homami, S.S. et al. Catalytic synthesis of dihydropyridines by domino reaction of terminal alkynes, carbodiimides, and acetylenic esters. Monatsh Chem 151, 1173–1181 (2020). https://doi.org/10.1007/s00706-020-02655-w

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  • DOI: https://doi.org/10.1007/s00706-020-02655-w

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