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2,4-Disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones: synthetic approaches to and consequent chemical modification

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Abstract

Arylideneketones are commonly considered as convenient starting materials for obtaining compounds of potential pharmaceutical interest. Heterocyclic α,β-unsaturated representatives of this series possess chemical and biological properties worth study in details. Particularly, substituted thiazole cycle, incorporated into such a system, allows obtaining of new biologically active products suitable to their consequent chemical modification. In this communication we focus attention on 2,4-disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones on the background of 2,4-dihalogen-5-formylthiazole, several relevant methods of their synthesis and prospective directions of further chemical modification.

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Acknowledgements

The authors express their gratitude to Enamine Ltd., Kyiv, Ukraine for providing chemicals, measuring all the necessary spectra and for any other kinds of support. This work was supported in part by the Research Grants of the Ministry of Education and Science of Ukraine (0118U002025 and 0119U002536). This work was performed using computational facilities of a joint computer cluster of SSI “Institute for Single Crystals” and Institute for Scintillation Materials of National Academy of Science of Ukraine incorporated into Ukrainian National Grid.

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Authors and Affiliations

  1. V. N. Karazin, Kharkiv National University, Kharkiv, 61022, Ukraine

    Oleksii O. Kolomoitsev, Volodymyr M. Kotliar, Dmytro O. Tarasenko & Andrey O. Doroshenko

  2. Enamine Ltd., Kiev, 02660, Ukraine

    Olexandre V. Buravov

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  1. Oleksii O. Kolomoitsev
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  2. Volodymyr M. Kotliar
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  3. Dmytro O. Tarasenko
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  4. Olexandre V. Buravov
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  5. Andrey O. Doroshenko
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Correspondence to Volodymyr M. Kotliar.

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Kolomoitsev, O.O., Kotliar, V.M., Tarasenko, D.O. et al. 2,4-Disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones: synthetic approaches to and consequent chemical modification. Monatsh Chem 151, 765–772 (2020). https://doi.org/10.1007/s00706-020-02612-7

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  • DOI: https://doi.org/10.1007/s00706-020-02612-7

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