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A simple adsorptive chronopotentiometric stripping method for determination of vitamin B1 in pharmaceutical products

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Abstract

A new electroanalytical method for vitamin B1 determination, based on adsorptive chronopotentiometric stripping analysis and non-specific adsorption onto mercury film electrode, was developed and validated. Stripping chronopotentiograms showed a single well-defined oxidation wave corresponding to vitamin B1 at about − 0.43 V in citrate buffer pH 6.0. The most important experimental factors affecting the monitored electroanalytical response of vitamin B1 were investigated and optimised. Under the optimal experimental conditions, linear response of vitamin B1 was obtained in the concentration range of 5–50 mg dm−3, with the achieved limit of detection of 1.64 mg dm−3, and the limit of quantitation of 4.97 mg dm−3. A mean recovery of 97.1% and relative standard deviations of 3.75% were achieved. The developed electrochemical procedure was successfully applied for the determination of vitamin B1 in pharmaceutical products. The results of the proposed method were in good agreement with those obtained by parallel HPLC analyses, confirming an accuracy of the developed method.

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Acknowledgements

The financial support of the Ministry of Education, Science and Technological Development of the Republic of Serbia (Project III 46009) is gratefully acknowledged.

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Authors and Affiliations

  1. Faculty of Technology, University of Novi Sad, Bul. cara Lazara 1, 21000, Novi Sad, Serbia

    Tanja Brezo-Borjan, Zorica Stojanović, Zvonimir Suturović, Snežana Kravić & Ana Đurović

  2. Institute of Food Technology, University of Novi Sad, Bul. cara Lazara 1, 21000, Novi Sad, Serbia

    Jovana Kos

Authors
  1. Tanja Brezo-Borjan
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  2. Zorica Stojanović
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  3. Zvonimir Suturović
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  4. Jovana Kos
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  5. Snežana Kravić
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  6. Ana Đurović
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Correspondence to Zorica Stojanović.

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Brezo-Borjan, T., Stojanović, Z., Suturović, Z. et al. A simple adsorptive chronopotentiometric stripping method for determination of vitamin B1 in pharmaceutical products. Monatsh Chem 151, 285–291 (2020). https://doi.org/10.1007/s00706-020-02567-9

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  • DOI: https://doi.org/10.1007/s00706-020-02567-9

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