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Simple and sensitive electrochemical determination of higenamine in dietary supplements using a disposable pencil graphite electrode

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Abstract

In this study, a cheap, rapid, simple, and modification-free electroanalytical methodology based on the disposable pencil graphite electrode is described for the quantification of higenamine (isoquinoline-type alkaloid having three phenolic OHs). At first, the electrochemical oxidation of higenamine was investigated in aqueous solutions by cyclic voltammetry. The electrode process is pH-dependent and controlled by a mixture of diffusion and adsorption processes. Higenamine yielded two well-separated oxidation steps in acidic, neutral, and alkaline media by using square-wave voltammetry. By using the first oxidation peak due to its higher sensitivity, there was an excellent correlation between oxidation peak current at + 0.44 V and higenamine concentration (as hydrochloride salt) in the range of 0.05 to 2.0 μg cm−3 (1.63 × 10−7–6.5 × 10−6 mol dm−3), with a detection limit of 0.014 μg cm−3 (4.55 × 10−8 mol dm−3) in Britton–Robinson buffer at pH 4.0. As an example, the developed approach can be used for the quantification of higenamine in the commercial dietary supplement formulations.

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References

  1. Ilag LL (2018) Med Res Innov 2:1

    Article  Google Scholar 

  2. Ahn K (2017) BMB Rep 50:111

    Article  CAS  Google Scholar 

  3. Ngo LT, Okogun JI, Folk WR (2013) Nat Prod Rep 30:584

    Article  CAS  Google Scholar 

  4. Calvert R, Vohra S, Ferguson M, Wiesenfeld P (2015) Food Chem Toxicol 78:207

    Article  CAS  Google Scholar 

  5. Lee SR, Schriefer JM, Gunnels TA, Harvey IC, Bloomer RJ (2013) Lipids Health Dis 12:148

    Article  Google Scholar 

  6. Sato S, Shirato K, Kizaki T, Ohno H, Tachiyashiki K, Imaizumi K (2012) J Phys Fit Sport Med 1:139

    Article  Google Scholar 

  7. Zhang N, Lian Z, Peng X, Li Z, Zhu H (2017) J Ethnopharmacol 196:242

    Article  CAS  Google Scholar 

  8. Cohen PA, Travis JC, Keizers PHJ, Boyer FE, Venhuis BJ (2019) Clin Toxicol 57:125

    Article  CAS  Google Scholar 

  9. Stajić A, Anđelković M, Dikić N, Rašić J, Vukašinović-Vesić M, Ivanović D, Jančić-Stojanović B (2017) J Pharm Biomed Anal 146:48

    Article  Google Scholar 

  10. Ryu JC, Song YS, Kim M, Cho JH, Yun-Choi HS (1993) Arch Pharm Res 16:213

    Article  CAS  Google Scholar 

  11. Okano M, Sato M, Kageyama S (2017) Drug Test Anal 9:1788

    Article  CAS  Google Scholar 

  12. Lo CF, Chen CM (1994) J Chromatogr B Biomed Sci Appl 655:33

    Article  CAS  Google Scholar 

  13. Grucza K, Kwiatkowska D, Kowalczyk K, Wicka M, Szutowski M, Cholbinski P (2018) Drug Test Anal 10:1017

    Article  CAS  Google Scholar 

  14. Hong H, Lee YI, Jin D (2010) Microchem J 96:374

    Article  CAS  Google Scholar 

  15. Feng S, Jiang J (2011) J Chromatogr B Biomed Sci Appl 879:763

    CAS  Google Scholar 

  16. Jae-Chun R, Yun-Seo S, Myungsoo K, Jung-Hyuck C, Hye Sook YC (1993) Arch Pharm Res (Seoul) 16:213

    Article  Google Scholar 

  17. Allahverdiyeva S, Talay Pınar P, Keskin E, Yunusoğlu O, Yardım Y, Şentürk Z (2020) Sens Actuators B 303:127174

    Article  CAS  Google Scholar 

  18. Sajid M, Baig N, Alhooshani K (2019) TrAC Trends Anal Chem 118:368

    Article  CAS  Google Scholar 

  19. Svítková J, Ignat T, Švorc Ľ, Labuda J, Barek J (2016) Crit Rev Anal Chem 46:248

    Article  Google Scholar 

  20. David IG, Popa D-E, Buleandra M (2017) J Anal Meth Chem. https://doi.org/10.1155/2017/1905968

    Article  Google Scholar 

  21. Kawde A-N, Baig N, Sajid M (2016) RSC Adv 6:91325

    Article  CAS  Google Scholar 

  22. Akanda MR, Sohail M, Aziz MA, Kawde A-N (2016) Electroanalysis 28:408

    Article  CAS  Google Scholar 

  23. Torrinha Á, Amorim CG, Montenegro MC, Araújo AN (2018) Talanta 190:235

    Article  CAS  Google Scholar 

  24. Rana A, Baig N, Saleh TA (2019) J Electroanal Chem 833:313

    Article  CAS  Google Scholar 

  25. Skrzypczynska K, Kusmierek K, Swiatkowski A, Dabek L (2018) Int J Electrochem Sci 13:88

    Article  CAS  Google Scholar 

  26. Levent A, Yardım Y, Şentürk Z (2009) Electrochim Acta 55:190

    Article  CAS  Google Scholar 

  27. Yardım Y, Keskin E, Levent A, Özsöz M, Şentürk Z (2010) Talanta 80:1347

    Article  Google Scholar 

  28. Keskin E, Yardım Y, Şentürk Z (2010) Electroanalysis 22:1191

    Article  CAS  Google Scholar 

  29. Levent A, Keskin E, Yardım Y, Şentürk Z (2011) Rev Anal Chem 30:45

    Article  CAS  Google Scholar 

  30. Yardım Y, Şentürk Z (2011) Turk J Chem 35:413

    Google Scholar 

  31. Yardım Y (2011) Rev Anal Chem 30:37

    Article  Google Scholar 

  32. Pınar PT (2020) Acta Chim Slov. https://doi.org/10.17344/acsi.2019.5367

    Article  Google Scholar 

  33. Öztürk F, Tasdemir IH, Altunöz Erdogan D, Erk N, Kılıc E (2011) Acta Chim Slov 58:830

    PubMed  Google Scholar 

  34. Rahayu RS, Noviandri I, Buchari B, Abdullah M, Hinoue T (2012) Int J Electrochem Sci 7:8255

    CAS  Google Scholar 

  35. Fotouhi L, Hashkavayi AB, Heravi MM (2013) J Exp Nanosci 8:947

    Article  CAS  Google Scholar 

  36. Shankar SS, Kumara Swamy BE, Mahanthesha KR, Sathisha TV, Vishwanath CC (2013) Anal Bioanal Electrochem 5:9

    Google Scholar 

  37. Silva LP, Vicentini FC, Lourencao BC, Oliveira GG, Lanza MRV, Fatibello-Filho O (2016) J Solid State Electrochem 20:2395

    Article  CAS  Google Scholar 

  38. Alipour E, Majidi MR, Saadatirad A, Golabi SM, Alizadeh AM (2013) Electrochim Acta 91:36

    Article  CAS  Google Scholar 

  39. Bard AJ, Faulkner LR (2000) Electrochemical methods: fundamentals and applications, 2nd edn. Wiley, NewYork

    Google Scholar 

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Van Yuzuncu Yil University, 65080, Van, Turkey

    Pınar Talay Pınar & Yavuz Yardım

  2. Department of Analytical Chemistry, Faculty of Science, Van Yuzuncu Yil University, 65080, Van, Turkey

    Zühre Şentürk

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  1. Pınar Talay Pınar
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  2. Yavuz Yardım
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  3. Zühre Şentürk
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Correspondence to Yavuz Yardım or Zühre Şentürk.

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Pınar, P.T., Yardım, Y. & Şentürk, Z. Simple and sensitive electrochemical determination of higenamine in dietary supplements using a disposable pencil graphite electrode. Monatsh Chem 151, 301–307 (2020). https://doi.org/10.1007/s00706-020-02556-y

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  • DOI: https://doi.org/10.1007/s00706-020-02556-y

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