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Zn/MCM-41-catalyzed unsymmetrical Hantzsch reaction and the evaluation of optical properties and anti-cancer activities of the polyhydroquinoline products

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Abstract

The three-component Hantzsch condensation of various aryl aldehydes, dimedone, and methyl 3-aminocrotonate was investigated in the presence of MCM-41-supported ZnNO3. The polyhydroquinoline products which were obtained under mild conditions and very easy workup were evaluated for anti-cancer activities against MCF-7, SK-BR-3, and HT-29 of breast and colon cancer cells. The fluorescence emission of some products was also studied and their optical parameters were reported.

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Acknowledgements

This project has been supported by a research grant of the university of Tabriz (number: 793). We thank research affairs of University of Tabriz for this grant. The University of Medical Sciences, Iran, is also gratefully appreciated for biological studies.

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Authors and Affiliations

  1. Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran

    Elaheh Farajzadeh Oskuie, Sajjad Azizi & Zarrin Ghasemi

  2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Sajjad Azizi

  3. Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran

    Mahtab Pirouzmand & Behnaz Nikzad Kojanag

  4. Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Jafar Soleymani

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  1. Elaheh Farajzadeh Oskuie
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  2. Sajjad Azizi
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  4. Mahtab Pirouzmand
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Correspondence to Zarrin Ghasemi.

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Oskuie, E.F., Azizi, S., Ghasemi, Z. et al. Zn/MCM-41-catalyzed unsymmetrical Hantzsch reaction and the evaluation of optical properties and anti-cancer activities of the polyhydroquinoline products. Monatsh Chem 151, 243–249 (2020). https://doi.org/10.1007/s00706-020-02549-x

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  • DOI: https://doi.org/10.1007/s00706-020-02549-x

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