Monatshefte für Chemie - Chemical Monthly

, Volume 150, Issue 3, pp 525–529 | Cite as

Lipid peroxidation and impaired vascular function in patients with type 1 diabetes mellitus

  • Tomáš PelclEmail author
  • Jan ŠkrhaJr.
  • Jan Šoupal
  • Milan Flekač
  • Petr Kačer
  • Jan Škrha
  • Tomáš Navrátil
  • Martin Prázný
Original Paper


Patients with type 1 diabetes mellitus (T1DM) develop microvascular complications during the course of the disease. Oxidative stress is the main mechanism of the microvascular damage. Currently no specific and reliable laboratory tests are available for screening of early microvascular changes. 56 patients with T1DM were included. We measured their serum levels of malonyl dialdehyde and reactive aldehydes with chain lengths C6–C12, which are known to be generated during lipid peroxidation, a process associated with oxidative stress. Serum levels of aldehydes were compared with the parameters of microvascular reactivity (MVR) examined by laser Doppler flowmetry and with the parameters of blood glucose control (glycated hemoglobin, glycemic variability using continuous glucose monitoring). In this cross-sectional observational study, higher levels of reactive aldehydes were associated with impaired skin MVR in T1DM. However, the parameters of glucose control were not associated with lipid peroxidation or MVR in our study. Therefore, we suggest that other than simple glycemic mechanism may be more important in the process of reactive aldehyde generation in T1DM.

Graphical abstract


Oxidative stress Diabetes mellitus Aldehydes Carbohydrates Radicals 



This work was partially funded by Research Project Progres Q25/LF1 and Grant 15-26705A of the Agency for Healthcare Research (AZV) of the Czech Republic.


  1. 1.
    Giacco F, Brownlee M (2010) Circ Res 107:1058CrossRefGoogle Scholar
  2. 2.
    Skrha J, Soupal J, Skrha J Jr, Prazny M (2016) Rev Endocr Metab Disord 17:103CrossRefGoogle Scholar
  3. 3.
    Kuricova K, Pacal L, Soupal J, Prazny M, Kankova K (2016) Diabetes Res Clin Pract 114:1CrossRefGoogle Scholar
  4. 4.
    The Diabetes Control and Complications Trial Research Group (1993) N Engl J Med 329:977CrossRefGoogle Scholar
  5. 5.
    Hirsch IB, Brownlee M (2005) J Diabetes Complications 19:178CrossRefGoogle Scholar
  6. 6.
    Soupal J, Skrha J Jr, Gajmon M, Horova E, Mraz M, Skrha J, Prazny M (2014) Diabetes Technol Ther 16:198CrossRefGoogle Scholar
  7. 7.
    Pena AS, Couper JJ, Harrington J, Gent R, Fairchild J, Tham E, Baghurst P (2012) Diabetes Technol Ther 14:457CrossRefGoogle Scholar
  8. 8.
    Service FJ (2013) Diabetes 65:1398CrossRefGoogle Scholar
  9. 9.
    Fuchs D, Dupon PP, Schaap LA, Drailer R (2017) Cardiovasc Diabetol 16:11CrossRefGoogle Scholar
  10. 10.
    Babos L, Jarai Z, Nemcsik J (2013) World J Nephrol 2:77CrossRefGoogle Scholar
  11. 11.
    Antus B (2016) Oxid Med Cell Longev 2016:2930434CrossRefGoogle Scholar
  12. 12.
    Fatima N, Faisal SM, Zubair S, Ajmal M, Siddiqui SS, Moin S, Owais M (2016) PLoS ONE 11:e0161548CrossRefGoogle Scholar
  13. 13.
    Horova E, Pelcl T, Soupal J, Skrha J Jr, Flekac M, Vejrazka M, Skrha J, Prazny M (2018) Diabetes Res Clin Pract 139:300CrossRefGoogle Scholar
  14. 14.
    Syslova K, Bohmova A, Mikoska M, Kuzma M, Pelclova D, Kacer P (2014) Oxid Med Cell Longev 2014:562860CrossRefGoogle Scholar
  15. 15.
    Pelclova D, Fenclova Z, Kacer P, Kuzma M, Navratil T, Lebedova J (2008) Ind Health 46:484CrossRefGoogle Scholar
  16. 16.
    Syslova K, Kacer P, Kuzma M, Najmonova V, Fenclova Z, Vlckova S, Lebedova J, Pelclova D (2009) J Chromatogr B Analyt Technol Biomed Life Sci 877:2477CrossRefGoogle Scholar
  17. 17.
    Pelclova D, Zdimal V, Kacer P, Fenclova Z, Vlckova S, Syslova K, Navratil T, Schwarz J, Zikova N, Barosova H, Turci F, Komarc M, Pelcl T, Belacek J, Kukutschova J, Zakharov S (2016) J Breath Res 10:016004CrossRefGoogle Scholar
  18. 18.
    Pelcl T, Skrha J Jr, Prazny M, Vlckova S, Fenclova Z, Navratil T, Malik J, Diblik P, Zikan V, Pelclova D (2018) Basic Clin Pharmacol Toxicol 123:356CrossRefGoogle Scholar
  19. 19.
    Pelclova D, Navratil T, Vlckova S, Fenclova Z, Pelcl T, Kacerova T, Kacer P (2018) Monatsh Chem 149:1579CrossRefGoogle Scholar
  20. 20.
    Pelclova D, Prazny M, Skrha J, Fenclova Z, Kalouskova M, Urban P, Navratil T, Senholdova Z, Smerhovsky Z (2007) Hum Exp Toxicol 26:705CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  1. 1.3rd Department of Internal Medicine, 1st Faculty of MedicineCharles University in PraguePragueCzech Republic
  2. 2.Biocev, Charles University, First Faculty of MedicineVestecCzech Republic
  3. 3.J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of SciencesPrague 8Czech Republic

Personalised recommendations