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N-Methylpiperidine assisted catalytic multicomponent reaction

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Abstract

A catalytic methodology involving terminal alkynes, elemental sulfur, and three-membered heterocycles has been described. This domino transformation serves as a useful method for the synthesis of oxathiolane and thiazolidine derivatives from the readily available starting materials. In situ generated copper acetylides reacted with elemental sulfur and oxiranes or aziridines in the presence of N-methylpiperidine as sulfur activating agent to form synthetically important heterocycles.

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Acknowledgements

We wish to thank for a grant from University of Zabol.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

    Zahra Keshtegar & Reza Heydari

  2. Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran

    Alireza Samzadeh-Kermani

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  1. Zahra Keshtegar
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  2. Reza Heydari
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  3. Alireza Samzadeh-Kermani
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Correspondence to Alireza Samzadeh-Kermani.

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Keshtegar, Z., Heydari, R. & Samzadeh-Kermani, A. N-Methylpiperidine assisted catalytic multicomponent reaction. Monatsh Chem 151, 213–222 (2020). https://doi.org/10.1007/s00706-019-02544-x

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  • DOI: https://doi.org/10.1007/s00706-019-02544-x

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