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Formation of 1,2,4-oxadiazole derivatives from Erlenmeyer azlactones and amidoximes

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Abstract

A convenient reaction between arylamidoximes and functionalized Erlenmeyer azlactones in MeCN at 80 °C is described. This method leads to the formation of novel (Z)-N-[2-aryl-1-(3-aryl-1,2,4-oxadiazol-5-yl)vinyl]benzamide derivatives in moderate to good yields. The structure of target compounds was confirmed by X-ray diffraction study.

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Acknowledgements

We thank the Research Council of Tarbiat Modares University for supporting this work.

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Authors and Affiliations

  1. Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran

    Issa Yavari & Asiyeh Amirahmadi

  2. Department of Inorganic Chemistry, Chemistry and Chemical Engineering Research Center of Iran, PO Box 14335-186, Tehran, Iran

    Mohammad Reza Halvagar

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  1. Issa Yavari
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  2. Asiyeh Amirahmadi
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  3. Mohammad Reza Halvagar
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Correspondence to Issa Yavari.

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Yavari, I., Amirahmadi, A. & Halvagar, M.R. Formation of 1,2,4-oxadiazole derivatives from Erlenmeyer azlactones and amidoximes. Monatsh Chem 150, 1857–1862 (2019). https://doi.org/10.1007/s00706-019-02486-4

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  • DOI: https://doi.org/10.1007/s00706-019-02486-4

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