100 years of mescaline

Abstract

In the hundred years since Ernst Späth’s synthesis of mescaline, it has been used in clinical research for many purposes, including the study of hallucinations, creativity, and schizophrenia. After Aldous Huxley described his experience with it in The Doors of Perception, it became a public sensation. During the 1960s it was largely replaced as a research compound by LSD. Today its scientific use is subject to strict controls, but the synthetic phenethylamines developed from it are widely used.

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References

  1. 1.

    Späth E (1919) Monatsh Chem 40:129

    Article  Google Scholar 

  2. 2.

    Beringer K (1969 [1927]) Der meskalinrausch. Springer, Berlin

  3. 3.

    Klüver H (1966 [1928/1942]) Mescal and mechanisms of hallucination. University of Chicago Press, Chicago

  4. 4.

    Witkiewicz SI (2018 [1932]) Narcotics: nicotine, cocaine, peyote, morphine, ether + appendices. Twisted Spoon Press, Dagenham

  5. 5.

    Marinesco MG (1933) Presse Médicale 1933:1864

    Google Scholar 

  6. 6.

    Slotta KH, Szyszka G (1933) Über β‐Phenyl‐äthylamine. III. Mitteilung: Neue Darstellung von Mescalin. Mitteilung aus dem Chemischen Institut der Universität Breslau, 29 June 1933

  7. 7.

    Guttman E, Maclay WS (1937) Br J Med Psychol 16:184

    Article  Google Scholar 

  8. 8.

    Maclay WS, Guttman E (1941) Arch Neurol Psychiatry 45:130

    Article  Google Scholar 

  9. 9.

    Stockings GT (1940) J Ment Sci 86:29

    Article  Google Scholar 

  10. 10.

    Smythies J (1953) Br J Philos Sci 3:339

    Article  Google Scholar 

  11. 11.

    Osmond H, Smythies J (1952) Br J Psychiatry 98:309

    CAS  Google Scholar 

  12. 12.

    Huxley A (1954/1956) The doors of perception and heaven and hell. Chatto and Windus, London

  13. 13.

    Tsao MU (1951) J Am Chem Soc 73:5495

    Article  Google Scholar 

  14. 14.

    Shulgin A, Shulgin A (1991) PIHKAL. Transform Press, Berkeley

    Google Scholar 

  15. 15.

    Jay M (2019) Mescaline: a global history of the first psychedelic. Yale University Press, New Haven

    Google Scholar 

Download references

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Correspondence to Mike Jay.

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Jay, M. 100 years of mescaline. Monatsh Chem 150, 957–959 (2019). https://doi.org/10.1007/s00706-019-02425-3

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Keywords

  • Mescaline
  • Hallucinations
  • Art
  • Psychiatry
  • LSD