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Synthesis of new 4-(1,2,3-triazolo)quinolin-2(1H)-ones via Cu-catalyzed [3 + 2] cycloaddition

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Abstract

In this investigation, new classes of 1,2,3-triazoles derived by 2-quinolone have been synthesized, via Cu-catalyzed [3 + 2] cycloadditions (Meldal-Sharpless ‘click’ reactions) of 4-azidoquinolin-2(1H)-ones with some alkynes. The structures of the products have been confirmed by different spectroscopic analyses.

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Acknowledgements

The NMR spectrometer at Florida Institute of Technology was purchased with assistance from the US National Science Foundation (CHE 03-42251).

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Minia University, El-Minia, 61519, Arab Republic of Egypt

    Essmat M. El-Sheref, Ashraf A. Aly & Mohamed A. Ameen

  2. Chemistry Department, Florida Institute of Technology, 150 W University Blvd, Melbourne, FL, 32901, USA

    Alan B. Brown

Authors
  1. Essmat M. El-Sheref
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  2. Ashraf A. Aly
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  3. Mohamed A. Ameen
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  4. Alan B. Brown
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Correspondence to Ashraf A. Aly.

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El-Sheref, E.M., Aly, A.A., Ameen, M.A. et al. Synthesis of new 4-(1,2,3-triazolo)quinolin-2(1H)-ones via Cu-catalyzed [3 + 2] cycloaddition. Monatsh Chem 150, 747–756 (2019). https://doi.org/10.1007/s00706-018-2342-4

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  • DOI: https://doi.org/10.1007/s00706-018-2342-4

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