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A chemoselective synthesis and biological evaluation of novel benzo[g]thiazolo[3,2-a]quinolone derivatives

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Abstract

A novel approach for chemoselective synthesis of functionalized benzo[g]thiazolo[3,2-a]quinolones from dithioacetals, cysteamine hydrochloride, 2-hydroxy-1,4-naphthoquinone, and aromatic aldehydes in ethanol is described. All products were tested in vitro for their cytotoxic effects on lung, breast, and prostate cancer cells.

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Acknowledgements

We are grateful to the University of Guilan and Imam Khomeini International University, Iran, for financial support.

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Authors and Affiliations

  1. Department of Chemistry, Imam Khomeini International University, Qazvin, Iran

    Mohammad Bayat, Shima Nasri & Fahimeh Sadat Hosseini

  2. Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran

    Fatemeh Safari

Authors
  1. Mohammad Bayat
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  2. Fatemeh Safari
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  3. Shima Nasri
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  4. Fahimeh Sadat Hosseini
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Corresponding authors

Correspondence to Mohammad Bayat or Fatemeh Safari.

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Bayat, M., Safari, F., Nasri, S. et al. A chemoselective synthesis and biological evaluation of novel benzo[g]thiazolo[3,2-a]quinolone derivatives. Monatsh Chem 150, 703–710 (2019). https://doi.org/10.1007/s00706-018-2337-1

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  • DOI: https://doi.org/10.1007/s00706-018-2337-1

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