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CAN-based oxidative annulation of alkenols with 1,3-dicarbonyl compounds

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Abstract

A mild protocol for the reaction of 1,3-dicarbonyl compounds with a range of alkenols mediated by CAN was described. The oxidative free radical cyclization leading to corresponding dihydrofuran derivatives tolerated the presence of hydroxyl group.

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Acknowledgements

This work was supported by the Grant Agency of the Slovak Republic (VEGA 1/0371/16). This contribution is also the result of the project: Research Center for Industrial Synthesis of Drugs, ITMS 26240220061, supported by the Research & Development Operational Programme founded by the ERDF.

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Authors and Affiliations

  1. Department of Organic Chemistry, Jagiellonian University, Gronostajowa 2, 30-387, Kraków, Poland

    Dariusz Cież & Krzysztof Kozieł

  2. NMR Laboratory, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, 832 32, Bratislava, Slovakia

    Branislav Horváth

  3. Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, 832 32, Bratislava, Slovakia

    Jan Světlík

Authors
  1. Dariusz Cież
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  2. Krzysztof Kozieł
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  3. Branislav Horváth
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  4. Jan Světlík
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Correspondence to Jan Světlík.

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Cież, D., Kozieł, K., Horváth, B. et al. CAN-based oxidative annulation of alkenols with 1,3-dicarbonyl compounds. Monatsh Chem 149, 1849–1855 (2018). https://doi.org/10.1007/s00706-018-2240-9

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  • DOI: https://doi.org/10.1007/s00706-018-2240-9

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