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Monatshefte für Chemie - Chemical Monthly

, Volume 149, Issue 8, pp 1447–1452 | Cite as

The synthesis of imidazoles and evaluation of their antioxidant and antifungal activities

  • Ramin Ghorbani-Vaghei
  • Vida Izadkhah
  • Jafar Mahmoodi
  • Roya Karamian
  • Masoumeh Ahmadi Khoei
Original Paper
  • 77 Downloads

Abstract

Tri- and tetra-substituted imidazole compounds were synthesized through in situ oxidation–condensation in the presence of catalytic amount of H2PW12O40¯ loaded on the ionic liquid-functionalized magnetic nanoparticles. Then, the antioxidant and antifungal activities of the new imidazoles were evaluated. The effectiveness of the samples as DPPH radical scavengers was confirmed by the measured IC50 values and thiophenyl-containing product showed the best IC50 of 0.12 when compared to the standard ascorbic acid. Moreover, all compounds have antifungal activity against Fusarium oxysporum.

Graphical Abstract

Keywords

Imidazole Antioxidant Fungicide Phosphotungstic acid Magnetic properties 

Notes

Acknowledgements

We are thankful to Bu-Ali Sina University, Center of Excellence in Development of Environmentally Friendly Methods for Chemical Synthesis (CEDEFMCS), for financial support.

Supplementary material

706_2018_2167_MOESM1_ESM.doc (5.8 mb)
Supplementary material 1 (DOC 5919 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  • Ramin Ghorbani-Vaghei
    • 1
  • Vida Izadkhah
    • 1
  • Jafar Mahmoodi
    • 1
  • Roya Karamian
    • 2
  • Masoumeh Ahmadi Khoei
    • 2
  1. 1.Faculty of ChemistryBu-Ali Sina UniversityHamedanIran
  2. 2.Department of Biology, Faculty of ScienceBu-Ali Sina UniversityHamedanIran

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