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Monatshefte für Chemie - Chemical Monthly

, Volume 149, Issue 6, pp 1093–1100 | Cite as

Facile synthesis of 3(2H)-furanones

Original Paper

Abstract

A practical method for the synthesis of 3(2H)-furanones including the bullatenone was described. Intramolecular cyclization of 4-hydroxyalkynones in the presence of KOH affords the biologically potent furanones in moderate-to-good yield at room temperature. Synthesis of 4-hydroxyalkynones from the reaction of acid chloride and terminal alkyne in the presence of copper iodide at room temperature was also reported.

Graphical abstract

Keywords

3(2H)-furanones 4-Hydroxyalkynone Annulation Cu-catalysis Bullatenone 

Notes

Acknowledgements

We are thankful to SERB (Ref. No. SB/S1/OC-21/2014), DST and CSIR (Ref. No. 02(0278)/16/EMR-II), Government of India for financial support.

Supplementary material

706_2018_2152_MOESM1_ESM.pdf (4.5 mb)
Supplementary material 1 (PDF 4565 kb)

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryNational Institute of Technology RourkelaRourkelaIndia

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