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Synthesis and characterization of some novel 4-arylglyoxal-chromene derivatives in the presence of a polymeric catalyst and biological evaluation against Escherichia coli

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Abstract

A poly(N-vinylimidazole)-catalyzed one-pot multicomponent reaction for the synthesis of 2-amino-4H-benzo[g]chromenes containing acyl group on the 4H-chromene ring has been developed. The products were obtained in generally good to excellent yields in the presence of low loading of poly(N-vinylimidazole) as a reusable basic catalyst via this synthetic strategy. Importantly, the catalyst has the unique ability of being easily separated and recycled. The products were screened for their antibacterial activity against Escherichia coli. The results of antibacterial studies showed that three 4-aroylchromene derivatives completely inhibited E. coli at 32 mg cm−3, whereas other derivatives were either moderately active or inactive up to 64 mg cm−3. Highest antimicrobial activity was observed when the phenylglyoxal hydrate was substituted with fluoro, nitro, and methoxy groups at para position.

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Acknowledgements

The author is grateful to staff members in the Analytical and Testing Center of Research House of Professor Reza for partial support and thankful to University of Malaya for the partial support of this work.

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Authors and Affiliations

  1. Nanotechnology and Catalysis Research Centre, NANOCAT, University of Malaya, Kuala Lumpur, Malaysia

    Nader Ghaffari Khaligh

  2. Research House of Professor Reza, Education Guilan, District 1, Rasht, 41569‐17139, Iran

    Nader Ghaffari Khaligh

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  1. Nader Ghaffari Khaligh
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Correspondence to Nader Ghaffari Khaligh.

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Khaligh, N.G. Synthesis and characterization of some novel 4-arylglyoxal-chromene derivatives in the presence of a polymeric catalyst and biological evaluation against Escherichia coli . Monatsh Chem 149, 33–38 (2018). https://doi.org/10.1007/s00706-017-2059-9

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  • DOI: https://doi.org/10.1007/s00706-017-2059-9

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