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Synthesis and antimicrobial activity evaluation of some novel water-soluble isatin-3-acylhydrazones

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Abstract

By acid-catalyzed reaction of substituted isatins with Girard’s reagent T, new water-soluble isatin-3-acylhydrazones were obtained with high yields. Their antimicrobial activity was evaluated. Selective activity against Gram-positive bacteria (S. aureus 209p and B. cereus 8035) and yeast-like fungus Candida albicans 855–653 along with low hematoxicity was established.

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Acknowledgements

The work was supported by Russian Science Foundation (Grant No. 14-50-00014).

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Authors and Affiliations

  1. A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia

    Andrei V. Bogdanov, Alexandra D. Voloshina, Anastasia S. Strobykina, Natalia V. Kulik, Julia K. Voronina, Ayrat R. Khamatgalimov & Vladimir F. Mironov

  2. Kazan National Research Technological University, Kazan, Russia

    Ilyuza F. Zaripova & Sergey V. Bukharov

Authors
  1. Andrei V. Bogdanov
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  2. Ilyuza F. Zaripova
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  3. Alexandra D. Voloshina
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  4. Anastasia S. Strobykina
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  5. Natalia V. Kulik
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  6. Sergey V. Bukharov
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  7. Julia K. Voronina
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  8. Ayrat R. Khamatgalimov
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  9. Vladimir F. Mironov
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Correspondence to Andrei V. Bogdanov.

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Bogdanov, A.V., Zaripova, I.F., Voloshina, A.D. et al. Synthesis and antimicrobial activity evaluation of some novel water-soluble isatin-3-acylhydrazones. Monatsh Chem 149, 111–117 (2018). https://doi.org/10.1007/s00706-017-2049-y

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  • DOI: https://doi.org/10.1007/s00706-017-2049-y

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