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Nano ZnO catalyzed green synthesis and cytotoxic assay of pyridinyl and pyrimidinyl bisphosphonates

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Abstract

A straight forward approach ensuring the anchoring of bisphosphonate moiety onto various pyridinyl and pyrimidinyl amines is described by the three-component reaction of an amine, diethyl phosphite, and triethyl orthoformate in the presence of catalytic amount of nano ZnO as an environmentally benign and heterogeneous catalyst under solvent-free microwave irradiation conditions. All the synthesized compounds are evaluated for anti-cell proliferation activity against human breast (MCF-7), prostate (DU-145), osteosarcoma (MG-63), fibrosarcoma (HT-1080), multiple myeloma (RPMI-8226) cancer cell lines using sulforhodamine-B (SRB) assay method, and adriamycin as a reference drug. All the title compounds showed promising cytotoxic activity on the five cell lines. One compound was two times more active than adriamycin on all the five cancer cell lines.

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Acknowledgements

The authors render their sincere thanks to Prof. C. Devendranath Reddy for his helpful discussions, and they are also grateful to DST-SERB, New Delhi, India for providing financial support through Project No. SB/S1/OC-96/2013, Dt. 05-11-2014 and anticancer drug screening facility in ACTREC, Tata Memorial Centre, Navi Mumbai for in vitro SRB assay of compounds for anticancer activity.

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Authors and Affiliations

  1. Organic and Medicinal Chemistry Division, Department of Chemistry, Sri Venkateswara University, Tirupati, 517 502, India

    Gundluru Mohan, Sarva Santhisudha, Nadiveedhi Maheshwara Reddy, Tellamekala Sreekanth, Sudileti Murali & Cirandur Suresh Reddy

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  1. Gundluru Mohan
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  2. Sarva Santhisudha
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  3. Nadiveedhi Maheshwara Reddy
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  4. Tellamekala Sreekanth
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  6. Cirandur Suresh Reddy
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Correspondence to Cirandur Suresh Reddy.

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Mohan, G., Santhisudha, S., Reddy, N.M. et al. Nano ZnO catalyzed green synthesis and cytotoxic assay of pyridinyl and pyrimidinyl bisphosphonates. Monatsh Chem 148, 1843–1851 (2017). https://doi.org/10.1007/s00706-017-2000-2

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  • DOI: https://doi.org/10.1007/s00706-017-2000-2

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