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Formulation development of matrix type transdermal patches containing mefenamic acid: physicochemical characterization and in vitro release evaluation

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Abstract

This research prepared the matrix type transdermal patches for mefenamic acid using ethylcellulose and Eudragit®RL as matrix layer and diethyl phthalates as plasticizer. They were prepared by dissolving all ingredients in the solvent and homogeneously mixing with the mefenamic acid powder by mechanical stirrer. Then, they were sonicated and poured into a Petri dish, and subsequently dried in hot air oven at 50 ± 2 °C. The mefenamic acid-loaded transdermal patches were evaluated and characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, and in vitro release. We found that crystallization of mefenamic acid affected the patches. However, when we increased the Eudragit®RL ratio as matrix layer, we found lower crystals characteristic of mefenamic acid in matrix patches. This was due to the fact that mefenamic acid could be dissolved in Eudragit®RL polymer more than ethylcellulose. The mefenamic acid powder showed the melting temperature at 233.50 °C; however, all matrix patches exhibited the melting point of mefenamic acid. The release profile showed a decrease of mefenamic acid release with increased Eudragit®RL ratio as a matrix layer. Thus, when increased the Eudragit®RL ratio, these matrix patches could reduce the crystalline effect of mefenamic acid, but it showed low release behavior of mefenamic acid from patches and was difficult to build the complete patches. The release behavior of all mefenamic acid patches followed the Higuchi’s model. The mefenamic acid patches could be easily prepared by simple method; however, in the future, these matrix patches will be developed to improve the crystallization effect of mefenamic acid.

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References

  1. Ansel HC, Popovich NG, Allen LV (1995) Pharmaceutical dosage forms and drug delivery system, 6th edn. Williams and Wikins, Malven

    Google Scholar 

  2. Hillery AM, Lloyd AW, Swarbrick J (2001) In: Hillery AM, Lloyd AW, Swarbrick J (eds) Drug delivery and targeting for pharmacists and pharmaceutical science. Taylor & Francis, New York

    Google Scholar 

  3. Barry BW (2001) Eur J Pharm Sci 14:101

    Article  CAS  Google Scholar 

  4. Chien YW (1992) In: Chien YW (ed) Novel drug delivery system, 2nd edn. Marcel Dekker, New York, p 301

    Google Scholar 

  5. Wokovich AM, Prodduturi S, Doub WH, Hussain AS, Buhse LF (2006) Eur J Pharm Biopharm 64:1

    Article  CAS  Google Scholar 

  6. Fan Q, Sirkar KK, Wu J (2009) J Membr Sci 337:175

    Article  CAS  Google Scholar 

  7. Chen C-H, Hsieh M-F, Ho Y-N, Huang C-M, Lee J-S, Yang C-Y, Chang Y (2011) J Membr Sci 371:134

    Article  CAS  Google Scholar 

  8. Tirnaksiz F, Yuce Z (2005) Il Farmaco 60:763

    Article  CAS  Google Scholar 

  9. Thein-Han WW, Stevens WF (2004) Drug Dev Ind Pharm 30:397

    Article  CAS  Google Scholar 

  10. Prodduturi S, Smith G, Wokovich A, Doub W, Westenberger B, Buhse L (2009) Pharm Res 26:1344

    Article  CAS  Google Scholar 

  11. Babu RJ, Pandit JK (2005) Int J Pharm 288:325

    Article  CAS  Google Scholar 

  12. Swathi CH, Subrahmanyam S, Kedarnath P (2011) Int J Pharm Tech 3:267

    Google Scholar 

  13. Sevgi F, Kaynarsoy B, Ertan G (2008) Pharm Dev Technol 13:5

    Article  CAS  Google Scholar 

  14. Güngör S, Yıldız A, Özsoy Y, Cevher E, Araman A (2003) Il Farmaco 58:397

    Article  Google Scholar 

  15. Adam A, Schrimpl L, Schmidt PC (2000) Drug Dev Ind Pharm 26:489

    Article  CAS  Google Scholar 

  16. Patel P, Madan P, Lin S (2014) Pharm Dev Technol 19:355

    Article  CAS  Google Scholar 

  17. Wen MM, Farid RM, Kassem AA (2014) J Liposome Res 24:280

    Article  CAS  Google Scholar 

  18. Khullar R, Kumar D, Seth N, Saini S (2012) Saudi Pharm J 20:63

    Article  Google Scholar 

  19. Kumar SV, Tarun P, Kumar TA (2013) Indo Am J Pharm Res 3:4269

    Google Scholar 

  20. Fang L, Numajiri S, Kobayashi D, Morimoto Y (2003) Int J Pharm 262:13

    Article  CAS  Google Scholar 

  21. Guyot M, Fawaz F (2000) Int J Pharm 204:171

    Article  CAS  Google Scholar 

  22. Costa P, Lobo JMS (2001) Eur J Pharm Sci 13:123

    Article  CAS  Google Scholar 

  23. ICH (1996) Guidance for industry; Q2B validation of analytical procedures: methodology. U.S. Department of Health and Human Service, Maryland

    Google Scholar 

  24. Dhanikula A, Panchagnula R (2004) AAPS J 6:88

    Article  Google Scholar 

  25. Cesur S, Gokbel S (2008) Cryst Res Technol 43:720

    Article  CAS  Google Scholar 

  26. Romero S, Escalera B, Bustamante P (1999) Int J Pharm 178:193

    Article  CAS  Google Scholar 

  27. Cilurzo F, Minghetti P, Casiraghi A, Tosi L, Pagani S, Montanari L (2005) Eur J Pharm Biopharm 60:61

    Article  CAS  Google Scholar 

  28. Jain P, Banga AK (2010) Int J Pharm 394:68

    Article  CAS  Google Scholar 

  29. Bruno L, Kasapis S, Heng PWS (2012) Int J Biol Macromol 50:385

    Article  CAS  Google Scholar 

  30. Agrawal AM, Manek RV, Kolling WM, Neau SH (2003) AAPS PharmSciTech 4:469

    Article  Google Scholar 

  31. Dash S, Murthy PN, Nath L, Chowdhury P (2010) Acta Pol Pharm 67:217

    CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the Faculty of Pharmacy and the Research Institute of Rangsit University for financial supports (Grant No. 74/2558). We thank Jebsen & Jessen NutriLife Ltd., Thailand for providing materials in this study.

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand

    Jirapornchai Suksaeree, Kotchakorn Piamsap, Supawan Paktham & Tichakorn Kenprom

  2. The Herbal Medicinal Products Research and Development Center, Faculty of Pharmacy, Rangsit University, Muang, Pathum Thani, 12000, Thailand

    Chaowalit Monton

  3. Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand

    Wiwat Pichayakorn

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  1. Jirapornchai Suksaeree
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  2. Kotchakorn Piamsap
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  3. Supawan Paktham
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  4. Tichakorn Kenprom
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  5. Chaowalit Monton
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Correspondence to Jirapornchai Suksaeree.

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Suksaeree, J., Piamsap, K., Paktham, S. et al. Formulation development of matrix type transdermal patches containing mefenamic acid: physicochemical characterization and in vitro release evaluation. Monatsh Chem 148, 1215–1222 (2017). https://doi.org/10.1007/s00706-017-1988-7

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  • DOI: https://doi.org/10.1007/s00706-017-1988-7

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