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Design and synthesis of basic ionic liquids for the esterification of triterpenic acids

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Abstract

We present the design and synthesis of Brønsted-basic ionic liquids and investigate their application in the microwave-assisted esterification of betulinic acid, aiming towards a benign and pyridine-free manufacturing process of the anti-HIV drug, bevirimat.

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Acknowledgements

We are grateful to Botanical Garden Vienna for the collections and supply of bark from platanus acerifola for the preparation of reference material. The X-ray centre of TU Wien is acknowledged for providing access to the single crystal diffractometer.

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Authors and Affiliations

  1. Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, 1060, Vienna, Austria

    Anna K. Ressmann, Maria Schneider, Peter Gaertner & Katharina Bica

  2. Institute for Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9/164-SC, 1060, Vienna, Austria

    Matthias Weil

Authors
  1. Anna K. Ressmann
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  2. Maria Schneider
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  3. Peter Gaertner
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  4. Matthias Weil
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  5. Katharina Bica
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Corresponding author

Correspondence to Katharina Bica.

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Ressmann, A.K., Schneider, M., Gaertner, P. et al. Design and synthesis of basic ionic liquids for the esterification of triterpenic acids. Monatsh Chem 148, 139–148 (2017). https://doi.org/10.1007/s00706-016-1889-1

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  • DOI: https://doi.org/10.1007/s00706-016-1889-1

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