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Intensified synthesis of [3,4-d]triazole-fused chromenes, coumarins, and quinolones


Efficient and metal-free synthesis of [3,4-d]triazole-fused chromenes, coumarins, and quinolones has been achieved in an intensified regime using microwave heating. The smooth 1,3-dipolar cycloaddition reaction of heterocyclic nitroalkenes with sodium azide provides a rapid entry into valuable heterocyclic scaffolds with potential biological properties.

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Funding was provided by the Austrian Science Funds (FWF, Grant No. P28243-B27).

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Correspondence to Toma Glasnov.

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Schwendt, G., Glasnov, T. Intensified synthesis of [3,4-d]triazole-fused chromenes, coumarins, and quinolones. Monatsh Chem 148, 69–75 (2017).

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  • Microwave-assisted synthesis
  • 1,3-Cycloaddition
  • Heterocycles
  • Catalyst-free