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Synthesis of new dihydropyrrol-2-one derivatives bearing sulfonamide groups and studies their antibacterial activity

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Abstract

A novel series of dihydropyrrol-2-one compounds bearing sulfonamide groups were synthesized and assayed for in vitro antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Streptococcus epidermidis bacteria. Antibacterial results showed that most of the compounds exhibited the antibacterial activity against P. aeruginosa and S. epidermidis and displayed no inhibition against S. aureus and E. coli. Interestingly, most of the screened compounds were more active than the reference drug trimethoprim-sulfamethoxazole against P. aeruginosa. Among them, one compound exhibited good antibacterial activity in comparison with the reference drugs against P. aeruginosa and may make it as potential an antibacterial agent.

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Acknowledgments

We are thankful to the Persian Gulf University Research Council for the partial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, 75169, Iran

    Masoume Bavadi & Khodabakhsh Niknam

  2. Department of Microbiology, Food and Drug Deputy, Bushehr University of Medical Sciences, Bushehr, Iran

    Marzieh Gharibi

Authors
  1. Masoume Bavadi
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  2. Khodabakhsh Niknam
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  3. Marzieh Gharibi
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Corresponding author

Correspondence to Khodabakhsh Niknam.

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Bavadi, M., Niknam, K. & Gharibi, M. Synthesis of new dihydropyrrol-2-one derivatives bearing sulfonamide groups and studies their antibacterial activity. Monatsh Chem 148, 1025–1034 (2017). https://doi.org/10.1007/s00706-016-1847-y

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  • DOI: https://doi.org/10.1007/s00706-016-1847-y

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