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One-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones by Fe3O4@SiO2-imid-PMAn nano-catalyst under ultrasonic irradiation and reflux conditions

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Abstract

Fe3O4@SiO2-imid-PMAn efficiently catalyzes the condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium salts to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives under ultrasonic irradiation or reflux conditions. This method gives notable advantages such as operational simplicity, excellent yields, short reaction times, and absence of any tedious workup or purification. In addition, the excellent catalytic performance and the easy preparation, thermal stability, and separation of the catalyst make it a good heterogeneous system and a useful alternative to other heterogeneous catalysts. Also, the aforementioned nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least six times without noticeable deterioration in catalytic activity and reaction yield.

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Acknowledgments

The authors are grateful to the council of the Iran National Science Foundation and University of Shiraz for their unending effort to provide financial support to undertake this work.

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Authors and Affiliations

  1. Chemistry Department, College of Science, Shiraz University, Shiraz, Iran

    Mohsen Esmaeilpour & Nafiseh Fahimi

  2. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Jaber Javidi

  3. Students Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Jaber Javidi

  4. Department of Science, Payame Noor University (PNU), Tehran, Iran

    Saeed Zahmatkesh

Authors
  1. Mohsen Esmaeilpour
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  2. Jaber Javidi
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  3. Saeed Zahmatkesh
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  4. Nafiseh Fahimi
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Corresponding author

Correspondence to Mohsen Esmaeilpour.

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Esmaeilpour, M., Javidi, J., Zahmatkesh, S. et al. One-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones by Fe3O4@SiO2-imid-PMAn nano-catalyst under ultrasonic irradiation and reflux conditions. Monatsh Chem 148, 947–956 (2017). https://doi.org/10.1007/s00706-016-1832-5

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  • DOI: https://doi.org/10.1007/s00706-016-1832-5

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