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Preparation of a novel magnetic and thermo-responsive composite and its application in drug release

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Abstract

A novel hyperbranched multi-arms star block copolymer with magnetic oriented target and thermo-responsive characters was synthesized. The atom transfer radical polymerization initiators were anchored on the surfaces of magnetic mesoporous silica by the chemical reaction of surface-modified amides with α-bromoisobutyryl bromide. The composites (FexOy@SBA-15@HPCMS-g-PNIPAAm) with magnetic mesoporous silica nanoparticles as core and hyperbranched star block copolymers as arms were prepared by iron(III)-mediated surface-initiated polymerization with FeCl3·6H2O as catalyst, PPh3 as ligand, ascorbic acid as reducing agent, N,N-dimethylformamide as solvent, and 4-chloromethylstyrene (CMS) and N-isopropylacrylaminde (NIPAAm) as monomer, respectively. The resultant materials were characterized by Fourier transform infrared, thermogravimetric analysis, N2 adsorption/desorption measurements, scanning electron microscopy, transmission electron micrographs, differential scanning calorimeter, and vibrating sample magnetometer. With aspirin as model drug, the drug release behavior of the hybrid materials was investigated in detail. Due to both the thermo-responsive and the magnetic property, the product may be used as a drug delivery system aiming at a cancer treatment.

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Acknowledgments

This work was sponsored by the financial supports from the National Natural Science Foundation of China (No. 21174057, 21404050), the National Basic Research Program of China (973 Program, No. 2012CB821500), Jiangsu Province for supporting this project under the innovation/entrepreneurship program (Surencaiban[2015]26), the Postdoctoral Science Foundation of China (No. 2015M580394), the Research Foundation of Jiangsu University (No. 14JDG059), and the Jiangsu Planned Projects for Postdoctoral Research Funds (No. 1402019A).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, China

    Zhiping Zhou, Tongfan Hao, Li Xia, Yijing Nie & Songjun Li

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  1. Zhiping Zhou
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  2. Tongfan Hao
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  3. Li Xia
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  4. Yijing Nie
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  5. Songjun Li
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Correspondence to Zhiping Zhou.

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Zhou, Z., Hao, T., Xia, L. et al. Preparation of a novel magnetic and thermo-responsive composite and its application in drug release. Monatsh Chem 148, 1205–1213 (2017). https://doi.org/10.1007/s00706-016-1827-2

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  • DOI: https://doi.org/10.1007/s00706-016-1827-2

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