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Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products

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Abstract

Tenoxicam and lornoxicam are nonsteroidal anti-inflammatory drugs, were subjected to photoirradiation at 254 nm led to the photodegradation of the pharmaceutical agents. Both, the isolated photodegradation products and the pharmaceutical agents were examined toward DNA binding and degradation. The photodegradation products degrade calf thymus in concentration dependent manner.

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Acknowledgments

The authors are grateful to the Deanship of Scientific Research at King Faisal University for the financial support (Project Number 160025).

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Authors and Affiliations

  1. Department of Chemistry, College of Science, King Faisal University, P. O. Box 400, Al Hufuf, Al Ahsa, 31982, Saudi Arabia

    Ibrahim Elghamry, Usama El-Ayaan, Magdy M. Youssef & Shar Al-Shihry

  2. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

    Usama El-Ayaan & Magdy M. Youssef

  3. Organisch-Chemisches Institut, Westf. Wilhelms-Universität Münster, Corrensstraße 40, 48149, Münster, Germany

    Matthias Letzel

  4. Organische Chemie I, Fakultät für Chemie, Universität Bielefeld, 33501, Bielefeld, Germany

    Jochen Mattay

Authors
  1. Ibrahim Elghamry
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  2. Usama El-Ayaan
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  3. Magdy M. Youssef
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  4. Shar Al-Shihry
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  5. Matthias Letzel
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  6. Jochen Mattay
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Correspondence to Ibrahim Elghamry.

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Elghamry, I., El-Ayaan, U., Youssef, M.M. et al. Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products. Monatsh Chem 148, 257–262 (2017). https://doi.org/10.1007/s00706-016-1765-z

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  • DOI: https://doi.org/10.1007/s00706-016-1765-z

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