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Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities

Monatshefte für Chemie - Chemical Monthly volume 148, pages 291–304 (2017)Cite this article

Abstract

4-Amino-5-(heptadec-8-en-1-yl)-4H-1,2,4-triazole-3-thiol was prepared for the first time and reacted with different reagents to yield new series of 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazoles, 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazines, and S- or N-substituted 3-mercapto-1,2,4-triazoles. The synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. These studies revealed that some of the screened compounds have promising antimicrobial and antioxidant activities.

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Authors and Affiliations

  1. Green Chemistry Department, National Research Centre (NRC), 33 El Bohouth Street (Former El Tahrir Street), Dokki, P.O. Box 12622, Giza, Egypt

    Hayam A. Abd El Salam, El-Sayed M. A. Yakout & Galal A. M. Nawwar

  2. Faculty of Science, Ain Shams University, Abbassia, Cairo, Egypt

    M. A. El-Hashash

  3. Pesticide Chemistry Department, National Research Centre, 33 El Bohouth Street (Former El Tahrir Street), Dokki, P.O. Box 12622, Giza, Egypt

    Abdel-Tawab H. Mossa

Authors
  1. Hayam A. Abd El Salam
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  2. El-Sayed M. A. Yakout
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  3. Galal A. M. Nawwar
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  4. M. A. El-Hashash
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  5. Abdel-Tawab H. Mossa
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Correspondence to El-Sayed M. A. Yakout.

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Abd El Salam, H.A., Yakout, ES.M.A., Nawwar, G.A.M. et al. Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities. Monatsh Chem 148, 291–304 (2017). https://doi.org/10.1007/s00706-016-1751-5

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  • DOI: https://doi.org/10.1007/s00706-016-1751-5

Keywords

  • Fatty acids
  • Triazole derivatives
  • Antimicrobial
  • Antioxidant activity