Skip to main content


Log in

Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities

  • Original Paper
  • Published:
Monatshefte für Chemie - Chemical Monthly Aims and scope Submit manuscript


4-Amino-5-(heptadec-8-en-1-yl)-4H-1,2,4-triazole-3-thiol was prepared for the first time and reacted with different reagents to yield new series of 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazoles, 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazines, and S- or N-substituted 3-mercapto-1,2,4-triazoles. The synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. These studies revealed that some of the screened compounds have promising antimicrobial and antioxidant activities.

Graphical abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others


  1. Shaker RM, Aly AA (2006) Phosphorus. Sulfur Silicon Relat Elem 181:2577

    Article  CAS  Google Scholar 

  2. Aytac SP, Tozkoparan B, Kaynak FB, Aktay G, Goktas O, Unuvar S (2009) Eur J Med Chem 44:4528

    Article  CAS  Google Scholar 

  3. Prakash O, Aneja DK, Hussain K (2011) Eur J Med Chem 46:5065

    Article  CAS  Google Scholar 

  4. Altintop M, Kaplancikli ZA, Zitouni GT (2011) Eur J Med Chem 46:5562

    Article  CAS  Google Scholar 

  5. Mohammad R, Ali S, Mahsa R, Mehdi B (2012) Heterocycl Commun 18:39

    Google Scholar 

  6. Badr SMI, Barwa RM (2011) Bioorg Med Chem 19:4506

    Article  CAS  Google Scholar 

  7. Kumar GVS, Prasad YR, Mallikarjuna BP, Chandrashekar SM (2010) Eur J Med Chem 45:5120

    Article  Google Scholar 

  8. El Shehry MF, Abu-Hashem AA, El-Telbani EM (2010) Eur J Med Chem 45:1906

    Article  Google Scholar 

  9. Holla BS, Akberali PM, Shivananda MK (2001) II Farmaco 56:919

    Article  CAS  Google Scholar 

  10. Al-Masoudi NA, Al-Soud YA (2008) Nucleosides. Nucleotides Nucleic Acids 27:1034

    Article  CAS  Google Scholar 

  11. Dutta K, Rangarajan PN, Vrati S, Basu A (2010) Curr Sci 98:326

    CAS  Google Scholar 

  12. Muhammad T, Abdul Wadood R, Zaheer U, Ajmal K, Iqbal C (2010) Eur J Med Chem 45:5200

  13. Barbuceanu SF, Saramet G, Almajan GL, Draghici C, Barbuceanu F, Bancescu G (2012) Eur J Med Chem 49:417

    Article  CAS  Google Scholar 

  14. El-Ebiary Nora MA, El-telbani EM, Nawwar GAM (2013) Lett Drug Des Discov 10:444

    Article  Google Scholar 

  15. Orhan İ, Özçelik B, Şener B (2011) Turk J Biol 35:251

    CAS  Google Scholar 

  16. Thibane VS, Kock JLF, Ells R, Van Wyk PWJ, Pohl CH (2010) Mar Drugs 8:2597

    Article  CAS  Google Scholar 

  17. Banday MR, Rauf A (2009) Indian J Chem 48:97

    Google Scholar 

  18. Hussain HH, Babic G, Durst T, Wright J, Flueraru M, Chichirau A, Chepelev LL (2003) J Org Chem 68:7023

    Article  CAS  Google Scholar 

  19. Abd El Salam H, Shaker NO, El-Telbani EM, Nawwar GAM (2009) J Chem Res 400

  20. Abd El-Salam H, Yakout El-Sayed MA, El-Hashash MA, Nawwar GAM (2013) Monatsh Chem 144:1893

  21. Audrieth IF, Scott ES, Kippur PS (1954) J Org Chem 19:733

    Article  CAS  Google Scholar 

  22. EL-Telbani EM, Swellem RH, Nawwar GAM (2007) Russ J Org Chem 43:1815

  23. Patrao P, Khader AMA, Kalluraya B, Vinayachandr (2013) Chem Pharm Res 5:326

  24. Mathew V, Keshavayya J, Vaidya VP, Giles D (2007) Eur J Med Chem 42:823

    Article  CAS  Google Scholar 

  25. Demirbas N, Demirbas A, Karaoglu SA, Celik E (2005) Arkivoc (i):820

  26. Tozkoparan B, Kupeli E, Yesilada E, Ertan M (2007) Bioorg Med Chem 15:1808

    Article  CAS  Google Scholar 

  27. De La Rosa M, Kim HW, Gunic E, Jenket C, Boyle U, Koh YH, Korboukh I, Allan M, Zhang W, Chen H, Xu W, Nilar S, Yao N, Hamatake R, Lang SA, Hong Z, Zhang Z, Girardet JL (2006) Bioorg Med Chem Lett 16:4444

    Article  Google Scholar 

  28. Wang Z, Wu B, Kuhen KL, Bursulaya B, Nguyen TN, Nguyen DG, He Y (2006) Bioorg Med Chem Lett 16:4174

    Article  CAS  Google Scholar 

  29. Bansal OP, Srinivas JS, Reddy Sastry CV (1992) Ind J Chem 31B:289

  30. Ye XX, Chem ZF, Zhang AJ, Zhang LX (2007) Molecules 12:1202

    Article  CAS  Google Scholar 

  31. Wu J, Liu X, Cheng X, Cao Y, Wang D, Li Z, Xu W, Pannecouque C, Witvrouw M, De Clereq E (2007) Molecules 12:2003

    Article  CAS  Google Scholar 

  32. Bauer W, Kirby WM, Sherris C, Turck M (1966) Am J Clin Pathol 45:493

    CAS  Google Scholar 

  33. Pfaller MA, Burmeister L, Bartlett MA, Rinaldi MG (1988) J Clin Microbiol 26:1437

    CAS  Google Scholar 

  34. Kato K, Terao S, Shimamoto N, Hirata M (1998) J Med Chem 31:793

    Article  Google Scholar 

  35. Padmaja, Payani T, Reddy GD, Padmavathi V (2009) Eur J Med Chem 44:4557

  36. Mossa AH, Heikal TM, Mohafrash SMM, Refaie AA (2015) J Appl Sci 15:69

    Article  CAS  Google Scholar 

  37. Ruch RJ, Cheng SJ, Klaunig JE (1989) Carcinogenesis 10:1003

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to El-Sayed M. A. Yakout.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abd El Salam, H.A., Yakout, ES.M.A., Nawwar, G.A.M. et al. Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities. Monatsh Chem 148, 291–304 (2017).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: