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Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities

Abstract

4-Amino-5-(heptadec-8-en-1-yl)-4H-1,2,4-triazole-3-thiol was prepared for the first time and reacted with different reagents to yield new series of 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazoles, 3-olyl-6-substituted [1,2,4]triazolo[3,4-b]thiadiazines, and S- or N-substituted 3-mercapto-1,2,4-triazoles. The synthesized compounds have been evaluated for their antimicrobial and antioxidant activities. These studies revealed that some of the screened compounds have promising antimicrobial and antioxidant activities.

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Correspondence to El-Sayed M. A. Yakout.

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Abd El Salam, H.A., Yakout, ES.M.A., Nawwar, G.A.M. et al. Synthesis of some new 1,2,4-triazoles containing olyl moiety and evaluation of their antimicrobial and antioxidant activities. Monatsh Chem 148, 291–304 (2017). https://doi.org/10.1007/s00706-016-1751-5

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Keywords

  • Fatty acids
  • Triazole derivatives
  • Antimicrobial
  • Antioxidant activity