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Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

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Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.

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Correspondence to Michael Schnürch.

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Schön, M., Dreier, D., Schnürch, M. et al. Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process. Monatsh Chem 147, 523–532 (2016). https://doi.org/10.1007/s00706-015-1605-6

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  • Continuous flow chemistry
  • Medicinal chemistry
  • Library synthesis
  • Diaminopyrimidines