Monatshefte für Chemie - Chemical Monthly

, Volume 147, Issue 3, pp 523–532

Library synthesis of cardiomyogenesis inducing compounds using an efficient two-step-one-flow process

  • Michael Schön
  • Dominik Dreier
  • Michael Schnürch
  • Marko D. Mihovilovic
Original Paper

DOI: 10.1007/s00706-015-1605-6

Cite this article as:
Schön, M., Dreier, D., Schnürch, M. et al. Monatsh Chem (2016) 147: 523. doi:10.1007/s00706-015-1605-6
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Abstract

Within this work we telescoped a batch laboratory scale synthesis towards a two-step-one-flow process to synthesize cardiomyogenesis inducing compounds (4,6-diaminopyrimidines) in continuous manner. Special attention was put on a quick and robust screening protocol and subsequent UHPLC analysis. Finally, the robustness of the method was proven by the multi-gram synthesis of VUT-MK142 using a laboratory scale continuous flow reactor, enabling to deliver enough material for extensive biological testing.

Graphical abstract

Keywords

Continuous flow chemistry Medicinal chemistry Library synthesis Diaminopyrimidines 

Supplementary material

706_2015_1605_MOESM1_ESM.docx (103 kb)
Supplementary material 1 (DOCX 103 kb)

Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Michael Schön
    • 1
  • Dominik Dreier
    • 1
  • Michael Schnürch
    • 1
  • Marko D. Mihovilovic
    • 1
  1. 1.TU WienInstitute of Applied Synthetic ChemistryViennaAustria

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