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Synthesis of new tetrahydropyridinylidene ammonium salts and their antiprotozoal potency

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Abstract

Several new tetrahydropyridinylidene ammonium salts were prepared by selective reduction. They were characterized using UV–Vis spectroscopy, FT-IR spectroscopy, and HRMS. Their structure was established by NMR spectroscopy and a single X-ray structure analysis. One compound shows a distinct antiplasmodial potency (IC50 = 0.34 μΜ) against the multiresistant K1-strain of Plasmodium falciparum and low cytotoxicity (IC50 = 199.8 μΜ) against L-6 cells (rat skeletal myoblasts).

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Authors and Affiliations

  1. Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria

    Werner Seebacher, Johanna Faist & Robert Weis

  2. Institute for Chemistry and Technology of Materials (ICTM), University of Technology, Graz, Austria

    Robert Saf

  3. Institute of Chemistry, University of Graz, Graz, Austria

    Ferdinand Belaj

  4. Swiss Tropical and Public Health Institute Basel and University of Basel, Basel, Switzerland

    Marcel Kaiser & Reto Brun

Authors
  1. Werner Seebacher
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  2. Johanna Faist
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  3. Ferdinand Belaj
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  4. Robert Saf
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  5. Marcel Kaiser
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  6. Reto Brun
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  7. Robert Weis
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Corresponding author

Correspondence to Werner Seebacher.

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Seebacher, W., Faist, J., Belaj, F. et al. Synthesis of new tetrahydropyridinylidene ammonium salts and their antiprotozoal potency. Monatsh Chem 146, 1299–1308 (2015). https://doi.org/10.1007/s00706-015-1503-y

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  • DOI: https://doi.org/10.1007/s00706-015-1503-y

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