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Iron(III) phosphate as a green and reusable catalyst for the synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles


Condensation reaction of aryl aldehydes, methyl ketones, malononitrile, and ammonium acetate in the presence of the green and recyclable catalyst FePO4 affords the corresponding 4,6-disubstituted 2-aminopyridine-3-carbonitriles. Some new derivatives of these compounds are synthesized. The catalyst can be also recycled and reused several times.

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Correspondence to Farahnaz K. Behbahani.

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Zadpour, M., Behbahani, F.K. Iron(III) phosphate as a green and reusable catalyst for the synthesis of 4,6-disubstituted 2-aminopyridine-3-carbonitriles. Monatsh Chem 146, 1865–1869 (2015).

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  • Condensation reaction
  • FePO4
  • Disubstituted pyridine
  • Arylnicotinonitrile