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Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents

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Abstract

A series of ten 1,3,4-oxadiazole-linked bisindole derivatives have been synthesized. All compounds were evaluated for anticancer activity against four human cancer cell lines (MCF-7, KB, Colo-205, and A-549). Most of these new compounds exhibited significant anticancer activity as compared to etoposide. Compounds’ GI50 values range from <0.1 to 3.9 μM, while the positive control etoposide has a GI50 in the range of 0.13–3.08 μM in the cell lines employed. Among them, four compounds showed a higher activity than etoposide.

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Acknowledgments

We are grateful to CSIR-IICT, Hyderabad, for providing analytical facilities.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, 522 510, Andhra Pradesh, India

    Islavathu Hatti, Reddymasu Sreenivasulu & Rudraraju Ramesh Raju

  2. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, 835 215, Jharkhand, India

    Surender Singh Jadav

  3. Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur, 302 023, Rajasthan, India

    Mohamed Jawed Ahsan

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  1. Islavathu Hatti
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  2. Reddymasu Sreenivasulu
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  3. Surender Singh Jadav
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  4. Mohamed Jawed Ahsan
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  5. Rudraraju Ramesh Raju
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Corresponding authors

Correspondence to Surender Singh Jadav, Mohamed Jawed Ahsan or Rudraraju Ramesh Raju.

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Hatti, I., Sreenivasulu, R., Jadav, S.S. et al. Synthesis and biological evaluation of 1,3,4-oxadiazole-linked bisindole derivatives as anticancer agents. Monatsh Chem 146, 1699–1705 (2015). https://doi.org/10.1007/s00706-015-1448-1

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  • DOI: https://doi.org/10.1007/s00706-015-1448-1

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