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Potassium hydroxide-promoted transition-metal-free synthesis of 4(3H)-quinazolinones

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Abstract

We have developed a KOH-promoted transition-metal-free synthesis of 2-substituted 4(3H)-quinazolinones from anthranilamides and benzyl alcohols or cinnamyl alcohol with air as oxidant. The protocol is simple, practical, and cost saving.

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Acknowledgments

We appreciate Allan Kipruto Chelashawʼs help. We thank the National Natural Science Foundation of China (No. 21372034) and the cultivating program for excellent innovation team of Chengdu University of Technology for financial support.

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Authors and Affiliations

  1. Institute of Green Catalysis and Synthesis, College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu, 610059, China

    Dezhi Qiu, Yanyan Wang, Dongming Lu, Lihong Zhou & Qingle Zeng

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  1. Dezhi Qiu
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  2. Yanyan Wang
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  3. Dongming Lu
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  4. Lihong Zhou
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  5. Qingle Zeng
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Correspondence to Qingle Zeng.

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Qiu, D., Wang, Y., Lu, D. et al. Potassium hydroxide-promoted transition-metal-free synthesis of 4(3H)-quinazolinones. Monatsh Chem 146, 1343–1347 (2015). https://doi.org/10.1007/s00706-015-1434-7

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  • DOI: https://doi.org/10.1007/s00706-015-1434-7

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