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Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities

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Abstract

This work describes a facile synthesis and characterization of a new series of pyrazole containing pyrimidine, 1,4-dihydropyridine, and imidazole derivatives using substituted 4-formylpyrazole as a key intermediate via multicomponent reaction sequence. The structures of these unknown compounds were elucidated by IR, 1H NMR, 13C NMR, LC–MS, and elemental analysis. The synthesized products were screened for their in vitro antimicrobial and antioxidant properties. Among the tested 3-(3,4-dihalophenyl)-1-phenyl-1H-pyrazol-4-yl, incorporated acetyl dihydropyrimidine compounds exhibited promising antimicrobial activity and DPPH radical scavenging activity with levels of inhibition at 89.4 and 83.3 %, respectively.

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Acknowledgments

The authors gratefully acknowledge the University Grants Commission (UGC) and Promotion of University Research and Scientific Excellence (PURSE) for the financial assistance. They are grateful to IISC Bangalore and USIC Mangalore University for providing the spectral analysis.

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Authors and Affiliations

  1. Department of Studies in Chemistry, Mangalore University, Mangalagangotri, 574199, Karnataka, India

    Shivapura Viveka,  Dinesha & Gundibasappa Karikannar Nagaraja

  2. Post Graduation Department of Biochemistry, St. Aloysius College, Mangalore, 575003, India

    Leelavathi Narayana Madhu

Authors
  1. Shivapura Viveka
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  2. Dinesha
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  3. Leelavathi Narayana Madhu
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  4. Gundibasappa Karikannar Nagaraja
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Correspondence to Gundibasappa Karikannar Nagaraja.

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Viveka, S., Dinesha, Madhu, L.N. et al. Synthesis of new pyrazole derivatives via multicomponent reaction and evaluation of their antimicrobial and antioxidant activities. Monatsh Chem 146, 1547–1555 (2015). https://doi.org/10.1007/s00706-015-1428-5

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  • DOI: https://doi.org/10.1007/s00706-015-1428-5

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