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Rapid cesium fluoride-catalyzed Knoevenagel condensation for the synthesis of highly functionalized 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives

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Abstract

A rapid, convenient, and environmentally friendly protocol was developed for the synthesis of functionalized 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) via a tandem Knoevenagel–Michael reaction by condensing pyrazolone with readily available differently substituted aldehydes and catalyzed by cesium fluoride at room temperature.

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Acknowledgments

The authors are grateful to the Organization for Prohibition of Chemical Weapons (OPCW), The Netherlands (Project No. L/ICA/ICB/173681/12) for financial support and DAAD (Deutscher Akademischer Austauschdienst), Bonn, Germany, for granting a fellowship to Prof. Dr. Khalid Mohammed Khan.

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Authors and Affiliations

  1. H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

    Khalid Mohammed Khan, Munira Taj Muhammad & Imran Khan

  2. PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, 75280, Pakistan

    Shahnaz Perveen

  3. Interfakultäres Institut für Biochemie, Universität Tübingen, Hoppe-Seyler-Str. 4, Tübingen, 72076, Germany

    Wolfgang Voelter

Authors
  1. Khalid Mohammed Khan
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  2. Munira Taj Muhammad
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  3. Imran Khan
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  4. Shahnaz Perveen
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  5. Wolfgang Voelter
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Corresponding author

Correspondence to Khalid Mohammed Khan.

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Khan, K.M., Muhammad, M.T., Khan, I. et al. Rapid cesium fluoride-catalyzed Knoevenagel condensation for the synthesis of highly functionalized 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives. Monatsh Chem 146, 1587–1590 (2015). https://doi.org/10.1007/s00706-015-1424-9

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  • DOI: https://doi.org/10.1007/s00706-015-1424-9

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