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Meglumine: an efficient, biodegradable, and recyclable green catalyst for one-pot synthesis of functionalized dihydropyridines

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Abstract

A green and efficient one-pot synthesis of functionalized dihydropyridines by four-component reaction of aldehydes, amine, malononitrile, and dimethyl acetylenedicarboxylate in presence of meglumine has been developed. The main advantages of this new methodology are reusability of catalyst, simplicity of the starting materials, short reaction time, one-pot and high yields of products.

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Acknowledgments

We thank the National Natural Science Foundation of China (21272053) for financial support.

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Authors and Affiliations

  1. Beijing General Research Institute of Mining and Metallurgy, Beijing, 100160, China

    Hong-Shuo Chen

  2. The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050024, China

    Rui-Yun Guo

Authors
  1. Hong-Shuo Chen
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  2. Rui-Yun Guo
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Correspondence to Hong-Shuo Chen.

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Chen, HS., Guo, RY. Meglumine: an efficient, biodegradable, and recyclable green catalyst for one-pot synthesis of functionalized dihydropyridines. Monatsh Chem 146, 1355–1362 (2015). https://doi.org/10.1007/s00706-015-1416-9

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  • DOI: https://doi.org/10.1007/s00706-015-1416-9

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