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A flexible one-pot synthesis of 8,10-dimethyl-12-aryl-9H-naphto[1′,2′:5,6]pyrano[2,3-d]pyrimidine-9,11-diones catalyzed by ZnO nanoparticles under solvent-free conditions

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Abstract

A new, convenient, and green procedure for the synthesis of naphthopyranopyrimidine-diones is described using a one-pot multi-component reaction of β-naphthol, 1,3-dimethylbarbituric acid, and various aryl aldehydes in the presence of ZnO nanoparticles, an effective and recyclable heterogeneous catalyst, under solvent-free conditions. This method provides excellent advantages, such as waste-free, simple work-up procedure, and excellent yield with high selectivity. The stability of the catalyst was investigated by determining its activity after recycling for six times without significant loss of its catalytic activity.

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Acknowledgments

The authors are grateful to Islamic Azad University, Qom Branch, Qom, I. R. Iran. Also authors are grateful to Dr. Raheleh Teymuri and Dr. Hossein Shahbazi-Alavi for their helps.

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Authors and Affiliations

  1. Department of Chemistry, Qom Branch, Islamic Azad University, Qom, I R Iran

    Mahboubeh Mohaqeq & Javad Safaei-Ghomi

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  1. Mahboubeh Mohaqeq
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  2. Javad Safaei-Ghomi
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Correspondence to Javad Safaei-Ghomi.

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Mohaqeq, M., Safaei-Ghomi, J. A flexible one-pot synthesis of 8,10-dimethyl-12-aryl-9H-naphto[1′,2′:5,6]pyrano[2,3-d]pyrimidine-9,11-diones catalyzed by ZnO nanoparticles under solvent-free conditions. Monatsh Chem 146, 1581–1586 (2015). https://doi.org/10.1007/s00706-015-1411-1

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