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Synthesis, characterization, and antioxidant activity of pyrazolic macrocycle

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Abstract

A series of macrocycles containing isoxazoline, dioxazole, and pyrazole were synthesized and characterized by IR, 1H, and 13C NMR, mass spectra, elemental analysis, and X-ray single crystal determination. The antioxidant activity of synthesized compounds was evaluated. One of the compounds exhibits potent DPPH radical scavenging activity, comparable to that of vitamin E.

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Acknowledgments

We are grateful to Changji University (Grant No. 2012SSQD020 and 2013 YJZD001) for the financial help.

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Authors and Affiliations

  1. Department of Chemistry and Applied Chemistry, Changji University, Changji, People’s Republic of China

    Hehua Zeng, Yongming Zeng, Lili Geng, Xueqin Li & Xianfeng Meng

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  1. Hehua Zeng
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  2. Yongming Zeng
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  3. Lili Geng
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  4. Xueqin Li
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  5. Xianfeng Meng
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Corresponding author

Correspondence to Yongming Zeng.

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Zeng, H., Zeng, Y., Geng, L. et al. Synthesis, characterization, and antioxidant activity of pyrazolic macrocycle. Monatsh Chem 146, 199–206 (2015). https://doi.org/10.1007/s00706-014-1298-2

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  • DOI: https://doi.org/10.1007/s00706-014-1298-2

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