Abstract
We have developed an efficient and environmentally benign one-pot procedure for synthesis of novel N-alkyl-2-aryl-5-phenylimidazo[1,2-c]quinazolin-3-amine derivatives by use of the Groebke–Blackburn–Bienaymé multicomponent reaction. The title compounds were synthesized in good yields from 2-phenylquinazolin-4-amine, aromatic aldehydes, and isocyanides in the presence of ammonium chloride under solvent-free conditions.
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We gratefully acknowledge partial financial support from Tehran University of Medicinal Sciences Research Council.
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Akbarzadeh, T., Ebrahimi, A., Saeedi, M. et al. Synthesis of novel 5-phenylimidazo[1,2-c]quinazolin-3-amine derivatives via Groebke–Blackburn–Bienaymé multicomponent reaction. Monatsh Chem 145, 1483–1487 (2014). https://doi.org/10.1007/s00706-014-1204-y
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DOI: https://doi.org/10.1007/s00706-014-1204-y