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Electrochemical and spectral characterization of the host-guest inclusion complex of the antiparasitic drug nitazoxanide with β-cyclodextrin

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Abstract

The formation of a host-guest inclusion complex of the antiparasitic drug nitazoxanide (NTZ) with β-cyclodextrin (β-CD) in aqueous solution has been characterized by electrochemical methods, cyclic and differential pulse voltammetry, and UV-Vis absorption spectroscopy. The nature of the host-guest inclusion complex between NTZ and β-CD has been elucidated. The experimental results confirmed the existence of 1:1 inclusion complex of NTZ with β-CD. The binding constants describing the extent of formation of the complexes have been determined, using Benesi-Hildebrand plots, using voltammetry and UV-Vis spectroscopy. NTZ exhibits an affinity for β-CD. A special configuration of the complex has been proposed.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Dumyat University, Dumyat, 34517, Egypt

    Abd-Elgawad Radi, Hossam M. Nassef & Abd-Elrahman El-Naggar

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  1. Abd-Elgawad Radi
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  2. Hossam M. Nassef
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  3. Abd-Elrahman El-Naggar
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Correspondence to Abd-Elgawad Radi.

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Radi, AE., Nassef, H.M. & El-Naggar, AE. Electrochemical and spectral characterization of the host-guest inclusion complex of the antiparasitic drug nitazoxanide with β-cyclodextrin. Monatsh Chem 145, 421–426 (2014). https://doi.org/10.1007/s00706-013-1109-1

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  • DOI: https://doi.org/10.1007/s00706-013-1109-1

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