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Monatshefte für Chemie - Chemical Monthly

, Volume 144, Issue 12, pp 1877–1882 | Cite as

Imidazole functionalized magnetic Fe3O4 nanoparticles as a novel heterogeneous and efficient catalyst for synthesis of dihydropyrimidinones by Biginelli reaction

  • Simin NazariEmail author
  • Shervin Saadat
  • Pegah Kazemian Fard
  • Maryam Gorjizadeh
  • Eshagh Rezaee Nezhad
  • Mozhgan Afshari
Original Paper

Abstract

Dihydropyrimidinone derivatives were synthesized in moderate to high yields in one-pot three-component condensation reactions from the corresponding aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of catalytic amounts of imidazole functionalized on magnetic nanoparticles as an efficient, non-toxic, reusable, and easily available catalyst under solvent-free conditions at 80 °C. Compared to the classical Biginelli reaction, this new method consistently has the advantage of excellent yields, short reaction times, and methodological simplicity. Furthermore, the nanomagnetic catalyst could be readily handled and removed from the reaction mixture via application of an external magnet, allowing straightforward recovery and reuse.

Graphical Abstract

Keywords

Dihydropyrimidinone Biginelli reaction Magnetic nanoparticles Imidazole 

Notes

Acknowledgments

We are grateful to the Islamic Azad University Sousangerd Branch for supporting this work.

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Simin Nazari
    • 1
    Email author
  • Shervin Saadat
    • 2
  • Pegah Kazemian Fard
    • 2
  • Maryam Gorjizadeh
    • 3
  • Eshagh Rezaee Nezhad
    • 4
  • Mozhgan Afshari
    • 3
  1. 1.Department of Chemistry, Sousangerd BranchIslamic Azad UniversitySousangerdIran
  2. 2.Faculty of Science, Ahvaz BranchIslamic Azad UniversityAhvazIran
  3. 3.Department of Chemistry, Shoushtar BranchIslamic Azad UniversityShoushtarIran
  4. 4.Department of ChemistryPayame Noor UniversityTehranIran

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