A green synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives using nanosilica-supported tin(II) chloride as a heterogeneous nanocatalyst

Abstract

Efficient, green, and straightforward synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives under favorable conditions has been achieved by reaction of urea/thiourea, aldehydes, and ethyl acetoacetate, using the synthetic potential of nanosilica-supported tin(II) chloride. It is noteworthy that the procedure has many advantages, for example excellent product yields, short reaction time, easy isolation of products, and reusability of catalyst.

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Acknowledgments

The authors are grateful to University of Kashan for supporting this work by Grant No. 159196/V.

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Correspondence to Javad Safaei Ghomi.

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Safaei Ghomi, J., Teymuri, R. & Ziarati, A. A green synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives using nanosilica-supported tin(II) chloride as a heterogeneous nanocatalyst. Monatsh Chem 144, 1865–1870 (2013). https://doi.org/10.1007/s00706-013-1068-6

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Keywords

  • Nano silica-supported tin(II) chloride
  • Heterogeneous catalysis
  • Biginelli reaction
  • One-pot synthesis