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Monatshefte für Chemie - Chemical Monthly

, Volume 144, Issue 12, pp 1865–1870 | Cite as

A green synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives using nanosilica-supported tin(II) chloride as a heterogeneous nanocatalyst

  • Javad Safaei GhomiEmail author
  • Raheleh Teymuri
  • Abolfazl Ziarati
Original Paper

Abstract

Efficient, green, and straightforward synthesis of 3,4-dihydropyrimidine-2(1H)-one/thione derivatives under favorable conditions has been achieved by reaction of urea/thiourea, aldehydes, and ethyl acetoacetate, using the synthetic potential of nanosilica-supported tin(II) chloride. It is noteworthy that the procedure has many advantages, for example excellent product yields, short reaction time, easy isolation of products, and reusability of catalyst.

Graphical Abstract

Keywords

Nano silica-supported tin(II) chloride Heterogeneous catalysis Biginelli reaction One-pot synthesis 

Notes

Acknowledgments

The authors are grateful to University of Kashan for supporting this work by Grant No. 159196/V.

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Copyright information

© Springer-Verlag Wien 2013

Authors and Affiliations

  • Javad Safaei Ghomi
    • 1
    Email author
  • Raheleh Teymuri
    • 1
  • Abolfazl Ziarati
    • 1
  1. 1.Department of Organic Chemistry, Faculty of ChemistryUniversity of KashanKashanIslamic Republic of Iran

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