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A green method for synthesis of 7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives catalyzed by N-methylpyrrolidone hydrosulfate ([Hnmp]HSO4) ionic liquid

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Abstract

An efficient and green approach for the synthesis of 7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives is described via one-pot, three-component condensation of arylpyruvic acids, thiosemicarbazide, and 2-bromoacetophenones in the presence of N-methylpyrrolidone hydrosulfate ([Hnmp]HSO4) ionic liquid as the catalyst and solvent. This green catalyst can be recycled several times without any substantial decrease in the yields and reaction rates. The catalyst loadings are high.

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Acknowledgments

We are grateful to Prof. Hu for discussions and Mr. Hao ChE for measuring the MS and NMR spectra.

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Authors and Affiliations

  1. College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, 050035, People’s Republic of China

    Sijie Liu, Lanxiang Shi, Jingyu He, Hongkun Yue & Ran Zhou

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  1. Sijie Liu
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  2. Lanxiang Shi
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  3. Jingyu He
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  4. Hongkun Yue
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  5. Ran Zhou
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Correspondence to Sijie Liu.

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Liu, S., Shi, L., He, J. et al. A green method for synthesis of 7H-thiazolo[3,2-b][1,2,4]triazin-7-one derivatives catalyzed by N-methylpyrrolidone hydrosulfate ([Hnmp]HSO4) ionic liquid. Monatsh Chem 145, 217–221 (2014). https://doi.org/10.1007/s00706-013-1009-4

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  • DOI: https://doi.org/10.1007/s00706-013-1009-4

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