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Thermo- and pH-sensitive hydrogels containing the β-cyclodextrin moiety for controlled protein release

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Abstract

In this study, two kinds of dual-stimuli-responsive (pH and temperature) hydrogels were prepared through the copolymerization of acrylic acid (hydrophilic monomer) and N-isopropylacrylamide (thermosensitive monomer) with a modified β-cyclodextrin crosslinker or N,N′-methylenediacrylamide in aqueous solution. The swelling properties of these hydrogels, including the pH and temperature dependences of their equilibrium swelling ratios, their shrinking kinetics, and their de-swelling behavior, were investigated. The protein bovine serum albumin was chosen as a model drug to measure their release behavior at different pH values and temperatures. The results revealed that the hydrogel that incorporated the β-cyclodextrin crosslinker exhibits improved properties and could have a wide range of potential uses in biomedicine.

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Acknowledgments

Financial support of this study by the China Postdoctoral Science Foundation (No. 2012M521007) and the Practice Innovation Training Program Projects for Jiangsu College Students (No. 2012JSSPITP1205) are gratefully acknowledged.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Jiangsu University, Zhenjiang, China

    Shiheng Zheng, Jie Hu, Xinglong Xu, Xiaoping Chen & Dan Shen

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  1. Shiheng Zheng
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  2. Jie Hu
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  3. Xinglong Xu
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  4. Xiaoping Chen
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  5. Dan Shen
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Correspondence to Jie Hu.

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Zheng, S., Hu, J., Xu, X. et al. Thermo- and pH-sensitive hydrogels containing the β-cyclodextrin moiety for controlled protein release. Monatsh Chem 145, 39–46 (2014). https://doi.org/10.1007/s00706-013-0989-4

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  • DOI: https://doi.org/10.1007/s00706-013-0989-4

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