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An improved and efficient synthesis for IPL576,092 and its analogues

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Abstract

An improved and efficient preparation of IPL576,092 was developed. The synthetic route involves selective allylic oxidation of ∆5-sterols and subsequent hydroboration–oxidation as the key steps. In addition, two analogues were readily synthesized from commercially available steroidal compounds in two steps in the same way.

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Acknowledgments

Thanks are due to Prof Fu-Chu Liu (Yunnan University) for helpful criticism of the manuscript. This work was supported by the National Natural Science Foundation of China (No. 20472070) and State University College of Innovative Experimental Projects (No. 101067319).

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Authors and Affiliations

  1. Key Laboratory of Medicinal Chemistry for Natural Resources (Ministry of Education), Yunnan University, Kunming, Yunnan, People’s Republic of China

    Jin Liu, Rong Huang & Hongyou Zhu

Authors
  1. Jin Liu
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  2. Rong Huang
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  3. Hongyou Zhu
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Correspondence to Jin Liu.

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Liu, J., Huang, R. & Zhu, H. An improved and efficient synthesis for IPL576,092 and its analogues. Monatsh Chem 144, 1081–1085 (2013). https://doi.org/10.1007/s00706-012-0920-4

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  • DOI: https://doi.org/10.1007/s00706-012-0920-4

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