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A facile access to 1,3,4-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of 3-arylsydnones with α,β-unsaturated ketones

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Abstract

A novel one-pot synthesis of 1,3,4-trisubstituted pyrazoles has been accomplished by 1,3-dipolar cycloaddition of α,β-unsaturated ketones and 3-arylsydnones in dry xylene. The structural identities of these compounds were confirmed on the basis of IR, NMR, mass spectral, and X-ray analysis.

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Acknowledgments

We are grateful to the Key SCI-Tech Innovation Team of Zhejiang Province (2010R5 0017) for financial help.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi, 830046, People’s Republic of China

    Fei Chen & Fang-Ming Liu

  2. College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou, 310036, People’s Republic of China

    Hai Shi & Sen-Lin Chen

Authors
  1. Fei Chen
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  2. Fang-Ming Liu
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  3. Hai Shi
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  4. Sen-Lin Chen
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Correspondence to Fei Chen.

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Chen, F., Liu, FM., Shi, H. et al. A facile access to 1,3,4-trisubstituted pyrazoles via 1,3-dipolar cycloaddition of 3-arylsydnones with α,β-unsaturated ketones. Monatsh Chem 144, 879–884 (2013). https://doi.org/10.1007/s00706-012-0901-7

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  • DOI: https://doi.org/10.1007/s00706-012-0901-7

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