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Synthesis and antimicrobial activity of novel gold(I) N-heterocyclic carbene complexes

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Abstract

Benzimidazolium salts and six anionic gold–NHC complexes (NHC = N,N’-dialkylbenzimidazol-2-ylidene) were prepared and characterized. Novel [Au(NHC)2]AuCl2-type complexes were prepared in good yields from silver–NHC complexes by treatment with [AuCl(PPh3)], following the commonly used silver carbene transfer route. All compounds were characterized using 1H and 13C NMR spectroscopy, elemental analysis, and IR. The gold complexes showed antimicrobial activity against Gram-positive/negative and fungal strains.

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Acknowledgments

This work was financially supported by the Technological and Scientific Research Council of Turkey TUBİTAK [TBAG (108T411)] and İnönü University Research Fund (İÜBAP: 2009/13).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Turkey

    Öznur Doğan, Nazan Kaloğlu, Serpil Demir, İlknur Özdemir & İsmail Özdemir

  2. Department of Microbiology, Faculty of Pharmacy, İnönü University, 44280, Malatya, Turkey

    Selami Günal

Authors
  1. Öznur Doğan
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  2. Nazan Kaloğlu
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  3. Serpil Demir
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  4. İlknur Özdemir
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  5. Selami Günal
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  6. İsmail Özdemir
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Correspondence to İsmail Özdemir.

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Doğan, Ö., Kaloğlu, N., Demir, S. et al. Synthesis and antimicrobial activity of novel gold(I) N-heterocyclic carbene complexes. Monatsh Chem 144, 313–319 (2013). https://doi.org/10.1007/s00706-012-0812-7

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  • DOI: https://doi.org/10.1007/s00706-012-0812-7

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