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Synthesis and characterization of poly(acrylic acid)-g-sodium alginate hydrogel initiated by gamma irradiation for controlled release of chlortetracycline HCl

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Abstract

pH-Sensitive hydrogel was synthesized by gamma radiation crosslinking for sodium alginate extracted from the marine brown alga Turbinaria decurrens and acrylic acid. Preparation of the hydrogels involved free radical polymerization of a combination of acrylic acid (w = 0.2) and different contents of sodium alginate (w = 0.05, 0.10, and 0.15) in aqueous solution using gamma rays of a 60Co source at an irradiation dose rate of 1.2 kGy/h. The swelling behavior of the prepared hydrogel was determined by investigating the swelling time, pH of medium, and alginate content in the hydrogel. The results showed that the hydrogel reached the equilibrium swelling state in water after 6 h. The hydrogel was found to be pH responsive. The drug loading and in vitro release properties of the hydrogel were also evaluated using chlortetracycline hydrochloride as the model drug. The adsorption isotherm studies by batching techniques under the effect of different initial feed concentrations of drug, different pH values, and different sodium alginate content of the adsorbent hydrogel were investigated. The diffusion of chlortetracycline hydrochloride within the hydrogel was found to be of non-Fickian character. The kinetic parameters such as the diffusion exponent, diffusion constant, and diffusion coefficient were also evaluated.

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Authors and Affiliations

  1. Microbial Biotechnology Department, National Research Center, Dokki, Cairo, Egypt

    Sahera F. Mohamed

  2. Faculty of Science, Jizan University, Jizan, Kingdom of Saudi Arabia

    Sahera F. Mohamed

  3. National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

    Ghada A. Mahmoud & Manal F. Abou Taleb

  4. Faculty of Science and Humanities, Salman Bin Abdul Aziz University, Alkharj, Kingdom of Saudi Arabia

    Manal F. Abou Taleb

Authors
  1. Sahera F. Mohamed
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  2. Ghada A. Mahmoud
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  3. Manal F. Abou Taleb
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Correspondence to Sahera F. Mohamed.

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Mohamed, S.F., Mahmoud, G.A. & Taleb, M.F.A. Synthesis and characterization of poly(acrylic acid)-g-sodium alginate hydrogel initiated by gamma irradiation for controlled release of chlortetracycline HCl. Monatsh Chem 144, 129–137 (2013). https://doi.org/10.1007/s00706-012-0776-7

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  • DOI: https://doi.org/10.1007/s00706-012-0776-7

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