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Monatshefte für Chemie - Chemical Monthly

, Volume 143, Issue 12, pp 1675–1680 | Cite as

Nafion-H®-catalyzed synthesis of polyhydroquinolines via the Hantzsch multicomponent reaction

  • Mazaahir KidwaiEmail author
  • Ritika Chauhan
  • Divya Bhatnagar
  • Abhay K. Singh
  • Biswajit Mishra
  • Sharmistha Dey
Original Paper

Abstract

A facile and efficient one-pot, four-component synthesis of polyhydroquinoline derivatives via the Hantzsch reaction using Nafion-H® as heterogeneous catalyst in PEG 400–water solvent system is described herein. The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times, and milder conditions with remarkable recyclability.

Graphical Abstract

Keywords

Nafion-H® Polyethylene glycol Polyhydroquinolines Recyclability Hantzsch reaction 

Notes

Acknowledgments

Ritika Chauhan is grateful to UGC (University Grants Commission) for providing junior research fellowship. We express our thanks to the Director of University Science and Instrumentation Centre, University of Delhi, Delhi, for providing the spectral data and also acknowledge the Head of the Biophysics Department, All India Institute of Medical Sciences, New Delhi, for carrying out the X-ray studies.

Supplementary material

706_2012_742_MOESM1_ESM.doc (83 kb)
Supplementary material 1 (DOC 83 kb)

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Mazaahir Kidwai
    • 1
    • 2
    Email author
  • Ritika Chauhan
    • 1
  • Divya Bhatnagar
    • 1
  • Abhay K. Singh
    • 3
  • Biswajit Mishra
    • 3
  • Sharmistha Dey
    • 3
  1. 1.Green Chemistry Research Laboratory, Department of ChemistryUniversity of DelhiDelhiIndia
  2. 2.Jiwaji UniversityGwaliorIndia
  3. 3.Department of BiophysicsAll India Institute of Medical SciencesNew DelhiIndia

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