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An improved catalytic method for the synthesis of 3,3-di(indolyl)oxindoles using Amberlyst 15 as a heterogeneous and reusable catalyst in water

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Abstract

Amberlyst 15 efficiently catalyzed the electrophilic substitution reaction of indoles with isatin derivatives to afford 3,3-di(indolyl)oxindoles in water. An important feature of this protocol is the reaction of 3-methyl-1H-indole with isatins to give the corresponding 3,3-diaryloxindole derivatives in high yields. The catalyst exhibited remarkable reusable activity.

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Acknowledgments

We are grateful to the Research Councils of Mazandaran University for their partial financial support.

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Authors and Affiliations

  1. Division of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, 47416, Babolsar, Iran

    Yaghoub Sarrafi, Marzieh Sadatshahabi & Nasibeh Norozipoor

  2. Tarbiat moallem of Dr. Shariaty, University of Payambare Aazam, Sari, Iran

    Kamal Alimohammadi

Authors
  1. Yaghoub Sarrafi
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  2. Kamal Alimohammadi
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  3. Marzieh Sadatshahabi
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  4. Nasibeh Norozipoor
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Correspondence to Yaghoub Sarrafi.

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Sarrafi, Y., Alimohammadi, K., Sadatshahabi, M. et al. An improved catalytic method for the synthesis of 3,3-di(indolyl)oxindoles using Amberlyst 15 as a heterogeneous and reusable catalyst in water. Monatsh Chem 143, 1519–1522 (2012). https://doi.org/10.1007/s00706-012-0723-7

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  • DOI: https://doi.org/10.1007/s00706-012-0723-7

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